TeraSolve – a new tool to measure tablet porosity and predict dissolution using THz spectroscopy

TeraSolve – a new tool to measure tablet porosity and predict dissolution using THz spectroscopy


For this project, we have developed a new measurement instrument called the TeraSolve. TeraSolve is an instrument, that allows us to measure the porosity of pharmaceutical tablets, using terahertz radiation. By measuring the porosity of a tablet, it is possible to predict the dissolution and disintegration behaviour. This technology, has the potential to transform the way, the pharmaceutical industry is implementing quality testing, during production. Having the potential to transform the quality of
medicines for all of us. At the heart of the system, is the TeraHertz engine. TeraView has developed this latest generation THz engine, specifically for industrial applications. With a modular design, it has a compact footprint and reduced weight. Active temperature stability ensures full functionality, in a wide range of production environments. In addition to this, we have developed, a bespoke, software suite for realtime prediction of tablet dissolution and disintegration properties. It can be interfaced, with the likes of SIPAT and PCA analysis packages, for further examination of the tableting process. The system shown here is stand-alone, with a manually loaded tablet handler. This can be adapted to allow automated feeding, with the aim of introducing the system in-line into production lines and continuous manufacturing lines. The terahertz technology is to be integrated into an at-line test system. A sample batch of product can be diverted to a feed system, dedicated for the analyser. Each tablet, will take approximately one second for the analysis providing rapid feedback for the process control. Research is currently being undertaken, to assess whether in-die readings can be taken on a tablet compaction simulator. This project has been a collaboration between us at the University of Cambridge, TeraView, Huxley Bertram and GSK.

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